ANCA positive crescentic glomerulonephritis outcome in a Central East European cohort: a retrospective study

Background The recently suggested distinct pathogenic pathways for myeloperoxidase(MPO) and proteinase 3(PR3) anti-neutrophilic cytoplasmic antibodies(ANCA) associated vasculitis could result in different modes of presentation and outcome. Moreover, kidney outcome was related to a new histopathologicclassification of pauci-immune glomerulonephritis. As reports were not always concordant, possible because differences in severity of organ lesions and ethnicity, we evaluated the outcome of a cohort of Central-East European patients with crescentic glomerulonephritisin relation with ANCA specificity and histopathologicalclassification.