Drug repurposing from the perspective of pharmaceutical companies
2018
Drug
repurposingholds the potential to bring medications with known safety profiles to new patient populations. Numerous examples exist for the identification of new indications for existing molecules, most stemming from serendipitous findings or focused recent efforts specifically limited to the mode of action of a specific drug. In recent years, the need for new approaches to drug research and development, combined with the advent of big data repositories and associated analytical methods, has generated interest in developing systematic approaches to drug
repurposing. A variety of innovative computational methods to enable systematic
repurposingscreens, experimental as well as through in silico approaches, have emerged. An efficient drug
repurposingpipeline requires the combination of access to molecular data, appropriate analytical expertise to enable robust insights, expertise and experimental set-up for validation and clinical development know-how. In this review, we describe some of the main approaches to systematic
repurposingand discuss the various players in this field and the need for strategic collaborations to increase the likelihood of success in bringing existing molecules to new indications, as well as the current advantages, considerations and challenges in
repurposingas a drug development strategy pursued by pharmaceutical companies. Linked Articles This article is part of a themed section on Inventing New Therapies Without
Reinventingthe
Wheel: The Power of Drug
Repurposing. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.2/issuetoc
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