TERT promoter mutations in sinonasal malignant melanoma: a study of 49 cases.

Sinonasal malignant melanoma (SNMM) comprises less than 1% of all melanomas and is located in the nasal cavityand the paranasal sinuses. The majority of SNMMs have unknown underlying oncogenic driver mutations. The recent identification of a high frequency of driver mutations in the promoter of the