Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
2016
Acute
lymphoblasticleukaemia is characterized by
chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.
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