Cytotoxicity of 6,16-Disubstituted analogues of (−)-Vincadifformine
2002
Abstract Eight analogues of (−)-16-chloro-1-dehydro-6 S -bromovincadifformine 1 were synthesized and evaluated for cytotoxicity in L1210 cell culture. None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure–activity relationships within this series.
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