The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17
2015
ErbB signalling is stimulated by the release of its ligands from the cell surface through metalloproteinase-dependent cleavage. Dombernowsky et al. show that this process is controlled by the sorting protein PACS-2, which enhances ErbB ligand release by regulating trafficking of the metalloprotease ADAM17.
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