The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes.

Bingbing Cheng,Chenchen Bing,Robert Staruch,Sumbul Shaikh,Michelle Wodzak Staruch,Debra Szczepanski,Noelle S. Williams,Theodore W. Laetsch,Rajiv Chopra

The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes.

2020

Bingbing Cheng
Chenchen Bing
Robert Staruch
Sumbul Shaikh
Michelle Wodzak Staruch
Debra Szczepanski
Noelle S. Williams
Theodore W. Laetsch
Rajiv Chopra

When doxorubicin (DOX) is administered via lyso-thermosensitive liposomes (LTLD), mild hyperthermia enhances localized delivery to heated vs. unheated tumors. The optimal LTLD dose and the impact o...

Keywords:

Targeted drug delivery
Liposome
mild hyperthermia
Doxorubicin
thermosensitive liposomes
Chemistry
Pharmacology

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