Association of H19 rs3741219 polymorphism with the susceptibility to uterine leiomyomas

Abstract Background Uterine leiomyomas (ULs) are non-cancerous tumors, originating from smooth muscle of uterine. Some evidence from genome-wide association studies (GWASs) has emphasized a link between UL and genetic background. Studies have shown the H19 overexpressed in the UL promotes the UL cells proliferation. The aim of this study was to evaluate the association between the H19 rs3741219 SNP and the risk of UL development. Materials and methods A total of 359 participants (155 UL patients and 204 age-matched healthy controls) were recruited for the study. Analysis of genotypes was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results The genotypic frequencies of H19 rs3741219 were TT (36.3%), TC (46.6%), and CC (17.1%) in the control group and TT (36.8%), TC (47.1%), and CC (16.1%) in the case group. The results from the regression analysis showed that there was no statistically significant association between H19 rs3741219 genotypic distribution and the risk of UL development with respect to allelic distribution. Also, there was no relation between H19 rs3741219 SNP and the risk of UL. Conclusion The results of our study showed no significant association between H19 rs3741219 SNP and the risk of UL risk.