Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency

Yaqian Duan,Ram Prasad,Dongni Feng,Eleni Beli,Sergio Li Calzi,Ana Leda F. Longhini,Regina Lamendella,Jason L. Floyd,Mariana Dupont,Sunil K. Noothi,Gopalkrishna Sreejit,Baskaran Athmanathan,Justin Wright,Amanda R. Jensen,Gavin Y. Oudit,Troy A. Markel,Prabhakara R. Nagareddy,Alexander G. Obukhov,Maria B. Grant

Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency

2019

Yaqian Duan
Ram Prasad
Dongni Feng
Eleni Beli
Sergio Li Calzi
Ana Leda F. Longhini
Regina Lamendella
Jason L. Floyd
Mariana Dupont
Sunil K. Noothi
Gopalkrishna Sreejit
Baskaran Athmanathan
Justin Wright
Amanda R. Jensen
Gavin Y. Oudit
Troy A. Markel
Prabhakara R. Nagareddy
Alexander G. Obukhov
Maria B. Grant

Rationale: There is incomplete knowledge of the impact of bone marrow (BM) cells on the gut microbiomeand gut barrier function. Objective: We postulated that diabetes and systemic angiotensin-conv...

Keywords:

Cardiology
Type 1 diabetes
Bone marrow
Biology
Internal medicine
Diabetes mellitus
Barrier function
Immunology
Microbiome
gut barrier
functional integrity
incomplete knowledge
gut microbiome

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