Primary CD30+ve cutaneous T-cell lymphoma associated with chronic burn injury in a patient with longstanding psoriasis
2004
An increased incidence of
lymphomahas been reported in psoriatic patients, but most cases are nodal
B-cell lymphoma. We report a unique case of
CD30-expressing
cutaneous T-cell lymphomaarising from underlying psoriatic plaque after intractable caustic burns and cellulitis in the palm of a patient with generalized chronic plaque psoriasis. Molecular studies confirmed a localized clonal T-cell expansion, and the lesion responded dramatically to multiagent chemotherapy. The case highlighted the possible role of chronic systemic and local T-cell activation in the pathogenesis of primary
CD30+ve
cutaneous T-cell lymphoma, and the importance of histologic assessment in chronic nonhealing skin lesions.
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