OpenTox Principles and Best Practices for Trusted Reproducible In Silico Methods Supporting Research and Regulatory Applications in Toxicological Science

Our aim in this work and initiative is to establish a practice and guidance for tracking and reporting modern in silicodata analyses in a reproduciblemanner. The recommended reproducibleprinciple supports the concept that data analyses, and more generally, scientific claims and regulatory evidence, are published with their raw dataand software code so that others may verify the findings and build upon them. We discuss here how we are demonstrating implementations of trusted reproduciblein silicoevidence workflows and are enhancing their acceptance with an open knowledgecommunity approach supported within OpenTox and OpenRiskNet. The general principlediscussed in this article can be applied in regulatory settings.