In vitro performances of a valved holding chamber with inhaled corticosteroids

Methods In this study, the VHC called Tipshaler (Protec’som, France) was evaluated with fluticasone (Flixotide, 50μg/dose, GSK, France) and beclomethasone (QVAR, 100μg/dose, MEDICIS, Canada). The method according to the European Pharmacopoeia used a constant flow rate (30 L / min) was used. Particle size distribution was measured using a NGI cascade impactor (Copley Scientific, Nottingham, United Kingdom). The fluticasone and beclomethasone concentrations were assayed by spectrophotometry at 236 nm and 239 nm respectively.