Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

Background There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discernfunction by using cell lines transduced with exogenous IDH mutant enzyme, in this study, we perform unbiased metabolomicsto discover metabolic differences between a cohort of patient-derived IDH1mutant and IDH wildtype gliomaspheres.