De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

Kai-En Chen,Qian Guo,Timothy A. Hill,Yi Cui,Amy Kendall,Zhe Yang,Ryan J. Hall,Michael D. Healy,Joanna Sacharz,Suzanne J. Norwood,Sachini Fonseka,Boyang Xie,Robert Reid,Natalya Leneva,Robert G. Parton,Rajesh Ghai,David A. Stroud,David P. Fairlie,Hiroaki Suga,Lauren P. Jackson,Rohan D. Teasdale,Toby Passioura,Brett M. Collins

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

2021

The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset Parkinson’s disease, while viral and...

Keywords:

Chemistry
Endosome
Retromer
VPS35
Mutation
Function (biology)
Retromer complex
Endosomal membrane
Cell biology
Protein subunit

Correction
Source
Cite
Save
Machine Reading By IdeaReader

111

References

Citations