Identification of CD4 and H-2K d -restricted cytotoxic T lymphocyte epitopes on the human herpesvirus 6B glycoprotein Q1 protein
2019
The identification of
Human herpesvirus 6B(HHV-6B)
epitopesthat are recognized by T-cells could contribute to the development of potential vaccines and
immunotherapies. Here, we identified CD4+ and H-2Kd-restricted CD8+ T-cell
epitopeson the glycoprotein Q1 of HHV-6B (BgQ1), which is a unique glycoprotein and essential for HHV-6B
viral entry, by using in vivo
electroporationwith a plasmid DNA encoding BgQ1, overlapping peptides spanning the BgQ1 sequence, ELISPOT assay for quantification of gamma interferon (IFN-γ), and computer-based T-cell
epitopeprediction programs. The CD4+ and CD8+ T-cell
epitopesidentified in BALB/c mice in this study could be a good animal model system for use in the development of T-cell responses, inducing HHV-6B vaccines or
immunotherapies.
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