Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARγ agonists

Abstract A series of 1,3-dicarbonyl compounds having 2(3 H )-benzazolonic heterocycles has been synthesized and tested for PPARγ agonist activity. SAR were developed and revealed that 6-acyl-2(3 H )-benzothiazolone derivatives with 1,3-dicarbonyl group were the most potent. IP administration of compound 22 exhibited comparable levels of glucose and triglyceride correction to PO administration of rosiglitazone in the ob / ob mouse studies.