Impact of expanding indications on surgical and oncological outcome in 1434 consecutive pancreatoduodenectomies

Abstract Background Over the years, high-volume pancreatic centers expanded their indications for pancreatoduodenectomy (PD) but with unknown impact on surgical and oncological outcome. Methods All consecutive PDs performed between 1992–2017 in a single pancreatic center were identified from a prospectively maintained database and analyzed according to three time periods. Results In total, 1434 patients underwent PD. Over time, more elderly patients underwent PD (P Conclusions In a period where indications for PD expanded, with more elderly patients, more advanced cancers and increased use of vascular resections, surgical outcome remained favorable and five-year survival for pancreatic cancer improved.