Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome

Abstract Study Objectives We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA). Methods Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains, which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity. Results Fifty-four children (median age 11.6 years) were included. Children with OSA (n=19, [obstructive apnea-hypopnea index] OAHI ≥2.h-1) had a higher plant gain compared with those without OSA (n=35), and it was positively correlated with AHI (r2=0.10, p Conclusion Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested.