Biodegradable Surfactants for Advanced Drug Delivery Strategies

Oxidative stress makes up common incidents in euka� ryotic metabolism. The presence of diverse components disturbing the equilibrium during oxygen metabolism increases oxidative dam� age unspecifically in living cells. Bodys own ubiquinone ( Q10) seems to be a promising drug in defending the heightened appearance of reactive oxygen species (ROS). Though, its lipophilic properties require a new strategy in drug formulation to overcome their low bioavailability. Consequently, the manufacture of heterogeneous nanodispersions is in focus for medical applications. The composition of conventional nanodispersions is made up of a drugconsisting core and a surfactive agent, also named as surfactant. Longtermed encap� sulation of the surfactive components into tissues might be the con� sequence of the use during medical therapeutics. The potential of provoking sideeffects is given by their nonbiodeg radable properties. Further improvements during fabrication process use the incorpora� tion of biodegradable components such as modified γ� polyglutamic acidwhich decreases the potential of prospective sideeffects. Keywords—Biopolymers, γ� Polyglutamic acid, Oxidative stress, Ubiquinone.