3 % Diclofenac in 2,5 % Hyaluronsäuregel zur Behandlung der Cheilitis actinica

Actinic cheilitis is a frequent manifestation of actinic dysplasia and requires early therapy to prevent its progression into invasive squamous cell carcinoma. A multitude of therapies, ranging from unspecific lesion adapted destructive techniques like laser to ambitious surgical field-management (vermillionectomy), are used. Field adapted, non destructive therapies like photodynamic therapy or, imiquimod recently got increasing awareness. 3 % diclofenac in 2.5 % hyaluronic acid has been used in actinic keratoses but has not been tested for the treatment of actinic cheilitis so far. We report about the treatment of actinic cheilitis with 3 % diclofenac in 2.5 % hyaluronic acid twice daily for 6 weeks in 6 patients with histological verified actinic cheilitis. 4 out of 6 patients showed clinical clearing of their actinic cheilitis 2 - 4 weeks after the end of treatment. Biopsies were taken from the treated areas at the final visit to verify clinical clearance. Side effects in most of the patients included a mild erythema and a mild to moderate swelling of the lips. In conclusion 3 % diclofenac in 2.5 % hyaluronic acid gel may be an easy to use, efficient, cosmetically more appealing alternative treatment of actinic cheilitis.