A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease
2017
Objective: To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose
coenzyme Q10(CoQ) will slow the
progressive functionaldecline of HD. Methods: We performed a multicenter randomized, double-blind, placebo-controlled trial. Patients with early-stage HD (n = 609) were enrolled at 48 sites in the United States, Canada, and Australia from 2008 to 2012. Patients were randomized to receive either CoQ 2,400 mg/d or matching placebo, then followed for 60 months. The primary outcome variable was the change from baseline to month 60 in Total Functional Capacity score (for patients who survived) combined with time to death (for patients who died) analyzed using a joint-rank analysis approach. Results: An
interim analysisfor futility revealed a conditional power of Conclusions: These data do not justify use of CoQ as a treatment to slow functional decline in HD. ClinicalTrials.gov identifier: NCT00608881. Classification of evidence: This article provides Class I evidence that CoQ does not slow the
progressive functionaldecline of patients with HD.
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