CDG: an online server proposing biologically closest disease-causing genes and pathologies

Summary: In analyses of exomedata, candidate geneselection can be challenging in the absence of variants in known disease- causing genes. We calculated the putative biologically closest known disease- causing genesfor 13,005 human genesnot currently reported to be disease- causing. We used these data to construct the Closest Disease- Causing Genes(CDG) server, which can be used to infer the closest associated disease- causing genesand phenotypes for lists of candidate genes. This resource will be a considerable asset for ascertaining the poten-tial relevance of lists of genesto specific diseasesof interest.