Lekowrażliwość bakterii wywołujących zakażenia układu moczowego u dzieci — obserwacje własne ośrodka

Background. Urinary tract infection (UTI) is one of the most common bacterial infection in children. Recurrent acute bacterial interstitial nephritisis likely to result in post-inflammatory nephropathy which may be followed by chronic kidney disease. Knowledge about current etiological factors of UTI in children and their sensitivity to drugs enables to select the appropriate empiric therapyand more effective treatment. Objectives. The occurrence of pathogens causing UTI in children and their sensitivity to drugs were analyzed. Material and methods. Medical records of children with UTI hospitalized in the Department of Pediatric Nephrology, Medical University of Lublin in 2009–2013 were studied. Results. In all children, Escherichia coliwas the most common invading pathogen. There was a statistically significant increase in the incidence of infection with Enterococcus spp . A significant decrease in sensitivity of Escherichia colito cefuroximewas shown. Strains of Klebsiella spp. were characterized by a significant decrease in sensitivity to co-trimoxazole and amoxicillin with clavulanic acid. In Proteus spp. case, a significant decrease in sensitivity to nitrofurantoinand significant increase in resistance to co-trimoxazole were demonstrated. Strains of Pseudomonas aeruginosa displayed a significant decrease in sensitivity to ceftazidimeand ciprofloxacin. Conclusions. 1. In all children, Escherichia coliwas the most common invading pathogen. 2. The majority of bacteria, which are most commonly isolated, increased their resistance to drugs widely used in the prevention of UTI i.e. nitrofurantoinand co-trimoxazole.