A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops
2019
Since Ronald Konopka and Seymour Benzer’s discovery of the gene Period in the 1970s, the
circadian rhythmfield has
diligentlyinvestigated regulatory mechanisms and intracellular transcriptional and translation feedback loops involving Period , and these investigations
culminatedin a 2017 Nobel Prize in Physiology or Medicine for Michael W. Young, Michael Rosbash, and Jeffrey C. Hall. Although research on 24-hour behavior rhythms started with Period , a series of discoveries in the past decade have shown us that
post-transcriptional regulationand protein modification, such as phosphorylation and oxidation, are alternatives ways to building a ticking clock.
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