Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma (S/R RCC) to reveal potential determinants of poor prognosis and response to immune checkpoint inhibitors (ICI).

Ziad Bakouny,David A. Braun,Sachet A. Shukla,Wenting Pan,Xin Gao,Yue Hou,Abdallah Flaifel,Amin Nassar,Sarah Abou Alaiwi,Ronan Flippot,John A. Steinharter,Pier Vitale Nuzzo,Yuko Ishii,Petra Ross-Macdonald,Gwo-Shu Mary Lee,David F. McDermott,Daniel Yick Chin Heng,Sabina Signoretti,Eliezer M. Van Allen,Toni K. Choueiri

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma (S/R RCC) to reveal potential determinants of poor prognosis and response to immune checkpoint inhibitors (ICI).

2020

715Background: S/R RCC are highly aggressive tumors but recent pilot clinical data have suggested that these tumors respond well to ICI. Our aim was to perform integrative molecular characterizatio...

Keywords:

Cancer research
Pathology
Immune checkpoint
Renal cell carcinoma
Medicine
poor prognosis
immune checkpoint inhibitors

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