Comparison of Newborn Screening Protocols for Congenital Adrenal Hyperplasia in Preterm Infants

Objective To compare 2 screening protocols performed concurrently in Minnesota: (1) liquid chromatography tandem mass spectrometrysteroid profiling as a second-tier test on positive fluoroimmunoassay (FIA) results; and (2) low-birthweight 3-screen protocol (FIA tests at Study design Population-based study of all Results First-tier testing of final dried blood spotresult (n = 6625) of the low-birthweight 3-screen protocol during 2006-2010 reduced the FP rate more than 5-fold ( P P Conclusion Timing of dried blood spotcollection rather than assay used played a more important role in reducing FP results of congenital adrenal hyperplasia newborn screeningin low birthweight infants.