Cytoprotecting-effect of cimetidine: experimental evidence in the rat gastric mucosal lesions induced by intragastric administration of necrotizing agents.
1983
Contradictory data have been found on
cimetidine-induced gastric
cytoprotection. In our paper the effect of
cimetidineadministered intraperitoneally in doses of 2.5, 10 and 50 mg X kg-1, on: 1. The
gastric acidsecretory responses in 1 and 4 hr
pylorus-ligated rats, and 2. The rat gastric mucosal lesions induced by intragastric administration of 0.6 M HCl, 0.2 M NaOH, 96% ethanol and 25% NaCl is discussed. It was found that: 1.
Cimetidinedose-dependently inhibited the
gastric acidsecretion in 1 and 4 hr
pylorus-ligated rats, but a dose of 2.5 mg X kg-1 did not exert any significant inhibition; 2. All doses of
cimetidinesignificantly prevented the gastric lesion development induced by different necrotizing agents (0.6 M HCl, 0.2 M NaOH, 96% ethanol, and 25% NaCl); 3. The
cytoprotectingdose of
cimetidinewas of 2.5 mg X kg-1; and 4. The duration of
cimetidine-induced
cytoprotectionwas 1 hr long before the administration of the necrotizing agent. These results suggest a real
cimetidine-induced gastric
cytoprotection.
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