Endoscopic findings of the gastric mucosa during long-term use of proton pump inhibitor – a multicenter study

AbstractBackground and aim: It is clinically important to diagnose drug-induced gastric lesions correctly. Recently, the use of proton pump inhibitors(PPI) has increased worldwide. The histological features induced by PPI have been reported; however, few reports have described endoscopicfindings induced by PPI. Therefore, we aimed to clarify the characteristic endoscopicfeatures in PPI users and associated pathogenic factors.Methods: We prospectively registered 1007 consecutive participants (70 PPI users and 937 nonusers) who underwent endoscopicexamination for cancer screening in three hospitals/clinics. Clinical data and endoscopicfindings were recorded in the registration forms. We compared the endoscopicfeatures between the two groups and evaluated contributing factors via univariate and multivariate analyses.Results: Multiple white elevated lesions (MWEL) and cobblestone-like mucosa (CLM) were more commonly observed in PPI users compared with nonusers (p < .01). Foveolar hyperplastic polyps wer...