Common variants of FTO and the risk of obesity and type 2 diabetes in Indians
2011
Common variants of fat mass and obesity-associated gene (
FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and
type 2 diabetesin population of European and non-European ethnicity. However, studies in Indian population have provided inconsistent results. Here, we examined association of eight
FTOvariants (rs1421085, rs8050136, rs9939609, rs9930506, rs1861867, rs9926180, rs2540769 and rs708277) with obesity and
type 2 diabetesin 5364 North Indians (2474
type 2 diabetespatients and 2890 non-diabetic controls) in two stages. None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed Body Mass Index (BMI)-dependent/independent association with
type 2 diabetes. However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population. Meta-analysis of the two study population results also revealed that rs1421085, rs8050136 and rs9939609 were significantly associated with BMI both under the random- and
fixed-effect models(P (random/fixed)=0.02/0.0001, 0.004/0.0006 and 0.01/0.01, respectively). In conclusion, common variants of
FTOwere associated with obesity, but not with
type 2 diabetesin North Indian population.
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