CASC15 polymorphisms are correlated with breast cancer susceptibility in Chinese Han women

Abstract Breast cancer (BC) is a prevalent malignant tumor among women. Numerous studies have been reported that lncRNAs were associated with various human diseases. In the current study, 681 BC patients and 680 unrelated controls were recruited to investigate the correlation between lncRNA CASC15 polymorphisms and BC risk in Chinese Han women. We performed SNPs genotyping using Agena MassARRAY platform. The relationship between lncRNA CASC15 polymorphisms and the risk of BC were evaluated through odds ratio (ORs) and 95% confidence interval (CI). Our results suggested that lncRNA CASC15 rs7740084 “G/G” genotype and rs1928168 “T/C” genotype significantly reduced BC risk in different genetic models (p = 0.045, p = 0.029 and p = 0.047, respectively). However, rs9393266 “C/T” and “C/T-T/T” genotypes were in correlation with the risk of BC (p = 0.021 and p = 0.048). In addition, we also observed that rs1928168 was related to the risk of BC in patients with age > 50 years old (p = 0.025), BMI > 24 status (p = 0.006) and tumor size (p = 0.035). For rs9393266, it was revealed that the “C/T” and “C/T-T/T” genotypes were related to BC risk in people with age ≤ 50 years old (p = 0.005) and BMI > 24 status (p = 0.023). In summary, our results revealed a potential interaction between lncRNA CASC15 polymorphisms and BC susceptibility. The results provided an important insight into lncRNA CASC15 function in the development of BC.