315. Alternating Magnetic Fields (AMF) and Antibiotics Eradicate Biofilm on Metal in a Synergistic Fashion

Background Hundreds of thousands of human implant procedures require surgical revision each year due to infection. Implant infections are difficult to treat with conventional antibiotics due to the formation of biofilm on the device surface. We have developed a non-invasive method to treat metal implant infections using alternating magnetic fields (AMF). The outer surface of a metal implant is heated when exposed to AMF, and we hypothesize that this heating can be used to eradicate biofilm or sensitize them to antibiotics (Fig 1). This study investigated the interaction of biofilm and antibiotics in vitro. Fig 1. Scheme showing the principle of AMF treating metal implant infection (MII).