A comparison of Ringer's lactate and acetate solutions and resuscitative effects on splanchnic dysoxia in patients with extensive burns
2010
Abstract We compared the effects of
Ringer's lactate(RL) and acetate (RA) solutions on parameters of
splanchnicdysoxia such as PgCO 2 (PCO 2 of
gastric mucosa) and pH i (pH of
gastric mucosa) using a gastric tonometer, in addition to blood markers such as the serum arterial level of lactate,
base excess,
ketone bodyratio, and
antithrombinduring the first 72h of the
resuscitationperiod in patients with burns covering 30% or more of their body surface. A prospective study was conducted in the university tertiary referral centers. There were no significant differences in the average age, TBSA (total burn surface area), and
resuscitativefluid volume during the first and second 24h between the two groups. In the RA group, PCO 2 gap values calculated employing the formula: PgCO 2 −PaCO 2 (arterial PCO 2 ), and pH gap calculated by: pH a (arterial pH)−pH i , improved to the normal ranges at 24h postburn, which was significantly faster than in the RL group. On the other hand, there were no significant differences in blood parameters between the two groups over the course. These results suggest that fluid
resuscitationwith RA may more rapidly ameliorate
splanchnicdysoxia, as evidenced by
gastric tonometry, compared to that with RL.
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