Expert consensus on endoscopic papillectomy using a Delphi process

ABSTRACT Background and Aims Consensus regarding an optimal algorithm for endoscopic treatment of papillary adenomas has not been established. We aimed to assess the existing degree of consensus among international experts and develop further concordance by means of a Delphi process. Methods A total of 52 international experts in the field of endoscopic papillectomy were invited to participate. Data were collected between August and December 2019 using an online survey platform. A total of 3 rounds were conducted. Consensus was defined as ≥70% agreement. Results Sixteen (31%) experts completed the full process, and consensus was achieved on 47 of the final 79 statements (59%). Diagnostic work-up should include at least an upper endoscopy using a duodenoscope (100%) and biopsies (94%). Selected use of additional abdominal imaging (75-81%). Patients with (suspected) papillary malignancy or over 1 cm intraductal extension should be referred for surgical resection (76%). To prevent pancreatitis, rectal nonsteroidal anti-inflammatory drugs should be administered before resection (82%) and a pancreatic stent should be placed (100%). A biliary stent is indicated in case of ongoing bleeding from the papillary region (76%) or concerns for a (micro) perforation after resection (88%). Follow-up should be started 3 to 6 months after initial papillectomy and repeated every 6 to 12 months for at least 5 years (75%). Conclusions This is the first step in developing an international consensus-based algorithm for endoscopic management of papillary adenomas. There were surprisingly many areas where consensus could not be achieved. These aspects should be the focus of future studies.