Systemic Metabolite Changes in Wild-type C57BL/6 Mice Fed Black Raspberries
2017
ABSTRACTIntroduction: Freeze-dried
black raspberries(BRBs) elicit chemopreventive effects against colorectal cancer in humans and in rodents. The objective of this study was to investigate potential BRB-caused
metabolitechanges using wild-type (WT) C57BL/6 mice. Methods and results: WT mice were fed either control diet or control diet supplemented with 5% BRBs for 8 wk. A nontargeted metabolomic analysis was conducted on colonic mucosa, liver, and fecal specimens collected from both diet groups. BRBs significantly changed the levels of 41 colonic mucosa
metabolites, 40 liver
metabolites, and 34 fecal
metabolitescompared to control diet-fed mice. BRBs reduced 34 lipid
metabolitesin colonic mucosa and increased levels of amino acids in liver. One
metabolite, 3-[3-(sulfooxy) phenyl] propanoic acid, might be a useful biomarker of BRB consumption. In addition, BRB powder was found to contain 30-fold higher levels of
linolenatecompared to control diets. Consistently, multiple omega-3 polyunsaturated fatty ...
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