Verrucous candidiasis of the lip: A harbinger of squamous cell carcinoma

Verrucous candidiasis (VC) of the oral mucosa can present with pseudocarcinomatous hyperplasia, often confused with squamous cell carcinoma (SCC). Here, we describe a case of florid VC secondary to fluconazole-resistant Candida albicans and report an initial significant response to oral posaconazole and surgical excisions. However, after 12 months of close follow-up, the patient's VC progressed to frank SCC, demonstrating the malignant potential of refractory VC cases.