The effects of intranasal esketamine (84 mg) and oral mirtazapine (30 mg) on on-road driving performance: a double-blind, placebo-controlled study

Rationale The purpose of this study is to evaluate the single dose effect of intranasal esketamine(84 mg) compared to placebo on on-road driving performance. Mirtazapine(oral, 30 mg) was used as a positive control, as this antidepressant drug is known to negatively affectdriving performance.