The features of bone articular lesions in dialysis-related amyloidosis (DRA) and criteria for the clinical diagnosis of DRA
2019
We introduced criteria for the clinical diagnosis of
dialysis-related
amyloidosis(DRA) from the
AmyloidosisResearch Group study supported by a Grant-in-Aid from the Ministry of Health, Labour and Welfare of Japan. DRA exhibits various kinds of bone articular lesions, such as
carpal tunnel syndrome,
trigger finger, destructive
spondyloarthropathy,
spinal canal stenosis, and
joint pains. These bone articular lesions, excluding destructive
spondyloarthropathy, are observed in non-
dialysispatients or
dialysispatients without DRA. We carefully compared these lesions between DRA and non-DRA patients and summarized the differences between them. The incidence age, male to female ratio, and coincidence rate were distinct between these groups of patients. Biopsies from bone articular lesions are invasive and burdensome for
dialysispatients; therefore, a precise clinical diagnosis is required for DRA. We discussed the validity and availability of our proposed criteria.
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