Characterization of the coupled plasma filtration–adsorption resin cartridge adsorptive capacity for cytokines and inflammatory mediators: adsorption profiles from septic patient plasma and in vitro endotoxin-stimulated whole blood

Coupled plasma filtration–adsorption (CPFA) is an extracorporeal therapy that uses plasma filtration associated with an adsorbent cartridge and hemofiltration in postdilution to remove cytokines and inflammatory mediators associated with septic shock and severe sepsis. We evaluated the adsorptive capacity of the resin cartridge to remove various inflammatory mediators and cytokines in vitro and ex vivo.