Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation.

Background Protein synthesis is tightly regulated and alterations to translation are characteristic of many cancers. Translation regulationis largely exerted at initiation through the eukaryotic translation initiation factor4 F (eIF4F). eIF4F is pivotal for oncogenicsignaling as it integrates mitogenic signals to amplify production of pro-growth and pro-survival factors. Convergence of these signals on eIF4F positions this factor as a gatekeeperof malignant fate. While the oncogenicproperties of eIF4F have been characterized, genome-wide evaluation of eIF4F translational output is incomplete yet critical for developing novel translation- targeted therapies.