PD‐L1 Expression and Deficient Mismatch Repair in Ductal Adenocarcinoma of the Prostate
2019
This study aimed to investigate the expression of programmed death receptor ligand 1 (
PD-L1) and deficient mismatch repair (dMMR) in ductal
adenocarcinomaof the prostate. A
tissue microarrayof 32 ductal and 42 grade-matched
acinar adenocarcinomaswas used. Slides were stained for
PD-L1, PD-L2, MMR proteins, CD4 and CD8.
PD-L1expression in tumor cells was only seen in 3% (1/34) of ductal and 5% (2/42) of
acinar adenocarcinomas(p = 1.0), while
PD-L1expression in tumor-infiltrating immune cells was seen in 29% (10/34) of ductal and 14% (6/42) of
acinar adenocarcinomas(p = 0.16). dMMR, as defined by loss of one or more of the MMR proteins, was identified in 5% (4/73) of cases, including 1 ductal and 3
acinar adenocarcinomas. There was a suggested association between infiltration of CD8+ lymphocytes and ductal subtype (p = 0.04) but not between CD4+ lymphocytes and tumor type (p = 0.28). The study shows that both dMMR and
PD-L1expression is uncommon in tumor cells of both ductal and
acinar adenocarcinomaof the prostate, while
PD-L1expression in tumor-infiltrating immune cells is a more common finding.
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