Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
2019
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling
sexual differentiation. In the agricultural pest
Ceratitis capitata(Mediterranean fruit fly, Medfly) we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a
Y chromosomecan be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the
Tephritidaefamily, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.
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