Annexin V expression and anti-annexin V antibodies in type 1 diabetes.

Background: AnnexinV (AnxV) has potent anticoagulant properties and regulatory functions for apoptosis and inflammation. Antibodies against annexinV (anti-AnxVs) may inhibit AnxV functions, leading to thrombosis during autoimmune diseases. Type 1 diabetesis an autoimmune diseaseand related with an ongoing autoimmune inflammation and thrombotic complications. There is no study evaluating anti-AnxVs/AnxV in a disease setting. Objective: The aim of this study was to evaluate the status of AnxV and anti-AnxVs in patients with type 1 diabetes. Methods: One hundred twenty-one patients with type 1 diabetesand 92 healthy controls were included in this study. Serum levels of AnxV and anti-AnxVs and expression of the AnxV gene and its common polymorphism in Kozak sequence (−1C>T) were studied. As a functional assay, the binding capacity of AnxV to platelets was evaluated. Results: As compared with controls, type 1 diabeticpatients had significantly low serum AnxV levels and AnxV gene expression. The number of...