Relationship between arterial and cisternal CSF oxygen tension in rabbits
1979
Oxygen tension was measured in samples of blood and
cisternal
cerebrospinal fluidtaken from anesthetized, paralyzed, and mechanically ventilated rabbits at various levels of arterial PO2.
Cerebrospinal fluidoxygen tension (CSF PO2) was correlated with arterial PO2 (linear regression equation PCSFO2 = 0.2472 Pao2 + 42.34). During hypoxia CSF PO2 was higher than arterial PO2 in most experiments. These data can be attributed to the
Bohr effect, which would increase the PO2 of the blood in
choroid plexuscapillaries as a result of its acidification. The acidification was suggested by Maren (Am. J. Physiol. 222: 885-889, 1972) to be a part of the ionic exchanges involved in
cerebrospinal fluidformation. Such a mechanism may be of importance for supporting
choroid plexusmetabolism and function during hypoxia. This mechanism is most clearly seen in the rabbit.
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