Abstract 18963: Clinical Significance of Daytime Vs. Nighttime Cheyne-stokes Respiration in Systolic Heart Failure Patients: Findings From 24- Hour Polygraphic Recordings

Purpose: Cheyne Stokes respiration, that is periodic apnea/ hyperpneaof central origin (CSR), has been separately described both during night (nCSR) and daytime (dCSR) in HF and associated with worse prognosis. The relationships between severity of nCSR and of dCSR have not yet been established. Methods: we enrolled 439 consecutive HF patients (aged 65±13 years, 76% males; NYHA class III-IV 33%, LVEF: 32±9%, mean±SD) on current guideline-directed therapy (96% betablockers, 94% ACE-inhibitors/ angiotensin receptorblockers, 22% CRT). All patients underwent a 24hour cardiorespiratory polygraphicrecording (nasal flow plus chest and abdomen respirograms) for detection of hypo/ apneaphenomenon, clinical and neurohormonalevaluation, cardiopulmonary exercise testing, echocardiography and Holter monitoring. Results: four groups were identified according to severity of nCSR (AHI 30, 29%) and dCSR (normal, apnea/hypopnea index, AHI <5, 38%; mild, 5 to ...