Initial neuropsychological profile of a series of 20 patients with logopenic variant of primary progressive aphasia.

Background: Logopenic variant of primary progressive aphasia(LPPA) is classically considered as an isolated languagedisorder, but verbal short-term memory deficit induces difficulties in neuropsychological teststhat are not intended to evaluate language. Objective: The aim of this study is to describe the initial symptoms and neuropsychologicalprofiles of LPPA. Methods: A retrospective study was conducted with a series of 20 consecutive patients diagnosed with LPPA. Clinical, neuroimaging, neuropsychological, and linguistic examinations are reported. The first neuropsychologicalexaminations (mean time between neuropsychological assessmentand diagnosis: 11 months) were then compared to 20 patients with mild cognitive impairment (MCI) and 20 patients with Alzheimer’s disease (AD) matched by age, gender, and educationlevel. Results: A recent onset or aggravation of anxiety disorders was frequently reported. An unusual neuropsychologicalprofile, different from that of AD or MCI, was observed: dissociation between verbal and visual memoryperformances, poor encoding performances on verbal memorytests, and preserved orientation to time, difficulties with mental calculationand fluency tasks. Biparetal abnormality and left hippocampal diaschisiswas frequently observed. Asymptomatic dopaminergic depletion was observed in four patients. Conclusion: Our study identifies that de novo or recently worsening anxiety and specific neuropsychologicalprofiles call for screening for LPPA, including a linguistic examination. Sometimes, there may be a continuum between LPPA and corticobasal syndrome.