The clinical outcomes of different eGFR strata and time in therapeutic range in atrial fibrillation patients with chronic kidney disease: a nationwide cohort study

Abstract Background Chronic kidney disease (CKD) is associated with increased risk of stroke, major bleeding ,morbidity and overall mortality in atrial fibrillation patients. The aim of this study is to demonstrate the effect of different eGFR strata and the TTR on clinical outcomes in AF patients with CKD. Methods NVAF patients were consecutively enrolled from hospitals across Thailand. eGFR were categorized into three different eGFR categories; eGFR >60 , 30-59 and 75%,TTR 60-75 and TTR 60, especially TTR>75 %, is associated with reduced risk of stroke/SSE, major bleeding and death irrespective of eGFR level. The combination of low TTR