Factors influencing platelet serotonin uptake in essential hypertension.

Abstract In a study of the mechanism(s) of platelet serotoninuptake alteration in essential hypertension, a total of 90 blood samples were analysed for platelet count and platelet serotoninuptake. These included 20 blood samples each of hypertensives, controls before and after cross-incubation experiments and 10 samples of hypertensives after control of blood pressure. It was observed that serotoninuptake was markedly reduced in hypertensive platelets. Diminished serotoninuptake in essential hypertensioncorrelated directly with diastolic and mean arterial blood pressure and inversely with plasma total cholesterol values. In cross-incubation experiments using control platelets and hypertensive plasma, there was a significant reduction in platelet serotoninuptake (303.06 ± 86.28 cpm/10 8 vs. 204.26 ± 66.45 cpm/10 8 ; P 8 vs. 312.64 ± 79.54 cpm/10 8 ; P 8 vs. 266.77 ± 61.68 cpm/10 8 ; P