Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona
2018
To promote drug delivery to exact sites and cell types, the surface of
nanocarriersis functionalized with targeting antibodies or ligands, typically coupled by covalent chemistry. Once the
nanocarrieris exposed to biological fluid such as plasma, however, its surface is inevitably covered with various biomolecules forming the protein
corona, which masks the targeting ability of the nanoparticle. Here, we show that we can use a pre-adsorption process to attach targeting antibodies to the surface of the
nanocarrier. Pre-adsorbed antibodies remain functional and are not completely exchanged or covered by the biomolecular
corona, whereas coupled antibodies are more affected by this shielding. We conclude that pre-adsorption is potentially a versatile, efficient and rapid method of attaching targeting moieties to the surface of
nanocarriers.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
50
References
109
Citations
NaN
KQI