Adenoid glioblastoma arising in a patient with neurofibromatosis type‐1
2005
An unusual case of
glioblastomawith
adenoidstructures arising in a 30-year-old Japanese woman with
neurofibromatosistype-1 (NF1) is reported. The patient was admitted to University of Miyazaki Hospital, complaining of headache, nausea and vomiting. From the
neuroradiologicalfindings the patient was diagnosed as having
glioblastoma, and the tumor was surgically resected. Histologically, the tumor consisted mainly of dark
basophilic cellsshowing prominent tubular or glandular structures surrounded by large eosinophilic cells, in addition to the typical
glioblastomafeatures in the periphery of the tumor. Both cells showed strong stainability with
glial fibrillary acidic protein(GFAP) and S-100 protein immunohistochemically, so that the tumor was classified as
adenoid
glioblastoma. Several cases of
glioblastomahave been reported to reveal the
adenoidor epithelioid differentiation. The patients with NF1 are prone to develop malignant tumors including
glioblastoma, but no cases representing
adenoid
glioblastomaassociated with NF1 have been reported. This report is considered to be the first case of
adenoid
glioblastomaarising in a patient with NF1. The recognition of the existence of epithelial features of
glioblastomawould be important in differential diagnosis of epithelioid tumors of the brain including
metastatic carcinomas.
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