Adenoid glioblastoma arising in a patient with neurofibromatosis type‐1

An unusual case of glioblastomawith adenoidstructures arising in a 30-year-old Japanese woman with neurofibromatosistype-1 (NF1) is reported. The patient was admitted to University of Miyazaki Hospital, complaining of headache, nausea and vomiting. From the neuroradiologicalfindings the patient was diagnosed as having glioblastoma, and the tumor was surgically resected. Histologically, the tumor consisted mainly of dark basophilic cellsshowing prominent tubular or glandular structures surrounded by large eosinophilic cells, in addition to the typical glioblastomafeatures in the periphery of the tumor. Both cells showed strong stainability with glial fibrillary acidic protein(GFAP) and S-100 protein immunohistochemically, so that the tumor was classified as adenoid glioblastoma. Several cases of glioblastomahave been reported to reveal the adenoidor epithelioid differentiation. The patients with NF1 are prone to develop malignant tumors including glioblastoma, but no cases representing adenoid glioblastomaassociated with NF1 have been reported. This report is considered to be the first case of adenoid glioblastomaarising in a patient with NF1. The recognition of the existence of epithelial features of glioblastomawould be important in differential diagnosis of epithelioid tumors of the brain including metastatic carcinomas.