Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
2017
Aims/hypothesis In humans,
glucagon-like peptide-1(GLP-1) is rapidly degraded by
dipeptidyl peptidase-4 to a relatively stable
metabolite, GLP-1(9–36)NH2, which allows measurement of GLP-1 secretion. However, little is known about the kinetics of the GLP-1
metabolitein mice. We hypothesised that the GLP-1
metaboliteis rapidly degraded in this species by neutral
endopeptidase(s) (NEP[s]).
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